Protein Modification Reagents
Medchemexpress LLC DSPE-PEG-DBCO sodium | 95.0% | 5000 Da | C65H104N3O12P | 5 MG
DSPE-PEG-DBCO sodium (MW 5000) is a PEGylated phospholipid provided as the sodium salt and designed for surface functionalization of liposomes and nanoparticles and for copper-free bioconjugation using DBCO-azide chemistry. It is supplied as a solid for research applications and is intended for use in drug delivery and bioconjugation studies.
- Provides DBCO functional group for strain-promoted azide-alkyne cycloaddition (copper-free click chemistry).
- PEG spacer (≈5000 Da) offers steric stabilization and reduces opsonization.
- Sodium salt form, solid, suitable for incorporation into lipid formulations.
- Reported high purity (~95.0%) for research-grade applications.
- Available in small research quantities for formulation and conjugation studies.
Medchemexpress LLC Dbco-peg4-va-pbd | 2241644-09-5 | >98.0% | 1430.6 | C80H87N9O16 | 10 MG
DBCO-PEG4-VA-PBD is a drug-linker conjugate designed for antibody-drug conjugate (ADC) research and click chemistry applications. It combines a dibenzocyclooctyne (DBCO) group for strain-promoted alkyne-azide cycloaddition (SPAAC) with a PEG4-valine-alanine spacer and a pyrrolobenzodiazepine (PBD) cytotoxic payload. The compound is supplied for research use and is handled under low-temperature, inert storage conditions.
- Contains DBCO group for strain-promoted alkyne-azide cycloaddition (SPAAC).
- Includes PEG4-valine-alanine spacer to provide linker stability.
- Delivers a pyrrolobenzodiazepine (PBD) cytotoxic payload for ADC applications.
- Molecular weight approximately 1,430.6 Da.
- Soluble in DMSO at 120 mg/mL; ultrasonic agitation recommended.
- Store at -80°C under nitrogen to maintain stability.
eMolecules 1644644-96-1 | Medchem Express | Methyltetrazine-Ph-NHS ester | 50mg | 736630605 | HY-130283 | MFCD28334557 | 327.3 | C15H13N5O4
Medchem Express | Desmorpholinyl Navitoclax-NH-Me | 5mg | 536984097 | HY-131232 | 2365172-82-1 | 918.550 | C44H51ClF3N5O5S3
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Medchemexpress LLC Azido-PEG4-Amido-Tris | 1398044-55-7 | 96.4% | C15H30N4O8 | 100 MG
Azido-PEG4-Amido-Tris is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. It functions as a click chemistry reagent, containing an Azide group that can participate in copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules possessing Alkyne groups. Additionally, it can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. PROTACs involve two distinct ligands connected by a linker, one for an E3 ubiquitin ligase and the other for the target protein, enabling the selective degradation of target proteins via the intracellular ubiquitin-proteasome system.
- PEG-based PROTAC linker
- Click chemistry reagent
- Contains an Azide group for CuAAc reaction
- Can undergo SPAAC reactions
- Used in the synthesis of PROTACs
Cayman Chemical Aceclofenac methyl ester 100mg
A potential impurity in commercial preparations of aceclofenac; has been used as a precursor in the synthesis of aceclofenac
Medchemexpress LLC Dbco-PEG4-VC-PAB-DMEA-PNU-159682 | 2259318-56-2 | 1695.81 g/mol | C86H106N10O26 | 1 MG
DBCO-PEG4-VC-PAB-DMEA-PNU-159682 is an ADC linker-drug conjugate designed for antibody-drug conjugate synthesis and click-chemistry conjugation. It contains a DBCO group for strain-promoted alkyne-azide cycloaddition, a four-unit PEG spacer for solubility, a valine-citrulline cleavable dipeptide with a para-aminobenzyl self-immolative spacer, and a DMEA-modified PNU-159682 payload.
- Facilitates SPAAC (strain-promoted alkyne-azide cycloaddition) for bioorthogonal conjugation.
- PEG4 spacer improves solubility and reduces steric hindrance.
- Val-Cit-PAB linker enables protease-cleavable payload release.
- Includes a potent PNU-159682-based payload for ADC research applications.
- Supplied in small research quantities suitable for conjugation studies.
Chemscene ChemScene | Mal-PEG6-NHS ester | 250MG | CS-0104984 | 0.98 | 1599472-25-9| MFCD20926374 | 530.52
ChemScene | Mal-PEG6-NHS ester | 250MG | CS-0104984 | 0.98 | 1599472-25-9| MFCD20926374 | 530.52
Medchemexpress LLC 4,7,10,13,16,19-Hexaoxa-22-azapentacosanoic acid, 25-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-2 3-oxo-, 2,5-dioxo-1-pyrrolidinyl ester | 1137109-21-7 | 98.8% | 601.60 | 250 MG
Mal-amido-PEG6-NHS ester is a PROTAC linker, based on PEG, that is utilized in the synthesis of PROTACs. PROTACs themselves are composed of two distinct ligands connected by a linker, where one ligand binds to an E3 ubiquitin ligase and the other to a target protein. These molecules function by leveraging the intracellular ubiquitin-proteasome system to achieve selective degradation of target proteins.
- Peg-based PROTAC linker.
- Used in the synthesis of PROTACs.
- PROTACs utilize the ubiquitin-proteasome system for selective protein degradation.
Medchemexpress LLC 2-(2-azidoethoxy)ethyl 4-methylbenzenesulfonate | 182347-24-6 | MFCD27946436 | 99.8% | 285.32 g/mol | C11H15N3O4S | 500 MG
N3-PEG2-Tos is an azide-terminated PEG2 tosylate linker used as a synthetic building block for organic synthesis and bioconjugation. The tosylate is a good leaving group for nucleophilic substitution, and the azide serves as a click-chemistry handle for rapid, selective conjugation under copper-catalyzed conditions.
- Azide functional group for copper-catalyzed azide-alkyne cycloaddition.
- Tosylate leaving group enables efficient nucleophilic substitution.
- Short PEG2 spacer provides flexibility and improved solubility in common organic solvents.
- High reported purity supports consistent reaction performance.
- Available in multiple package sizes to suit different synthesis scales.
Medchemexpress LLC Dbco-peg3-vc-exatecan | 2754384-70-6 | 96.7% | 1331.44 | C71H79FN10O15 | 5 MG
DBCO-PEG3-VC-Exatecan is a research-grade drug-linker conjugate that couples a cleavable DBCO-PEG3-VC linker to the topoisomerase I inhibitor exatecan, supplied as an off-white to light yellow solid for use in antibody-drug conjugate (ADC) research.
- adc drug-linker conjugate for preclinical and conjugation work
- contains exatecan, a DNA topoisomerase I inhibitor
- cleavable DBCO-PEG3-VC linker suitable for bioconjugation
- high reported purity for research applications
- available in small milligram quantities for formulation and testing
Medchemexpress LLC Dspe-peg-maleimide, MW 5000 | 99.8% | 100 MG
Dspe-peg-maleimide, MW 5000, is a linker lipid containing DSPE phospholipid and Maleimide. This compound is used in the synthesis of various liposomes and as a linker in immunoliposome synthesis for laboratory applications.
- Contains DSPE phospholipid and Maleimide.
- Utilized in liposome synthesis (HELDC, sterically stabilized, and immunoliposomes).
- Can be coupled with thiol-p5314-29 peptide for immunoliposome synthesis.
- Sterically stabilized liposomes can be coupled with thiolated monoclonal antibody OX26 (OX26-SH).
- HELDC liposomes with 3% DSPE-PEG-maleimide maintain particle size stability over two weeks (avg. 120 nm diameter).
- Molecular weight: 5000 (average).
- Appears as a white to off-white solid.
- For research use only.
Medchemexpress LLC NH2-PEG4-DOTA | 2090232-34-9 | 97.0% | 622.71 g/mol | C26H50N6O11 | 10mg
NH2-PEG4-DOTA is a bifunctional DOTA-type metal chelator NH2-PEG4-DOTA can be conjugated with Dextran for quantitative analysis in the presence of a highly luminescent complex NH2-PEG4-DOTA can also bind to radionuclides to prepare radionuclide drug conjugates (RDCs) RDCs have the ability to specifically target biomolecules and can be used in medical imaging or therapy
eMolecules 5961-83-1 | Bis-PEG1-acid | Broadpharm | MFCD06208032 | 162.141 | C6H10O5 | 97.000 | OC(=O)CCOCCC(O)=O | 250mg | 279709653
Bis-PEG1-acid | Broadpharm | 5961-83-1 | MFCD06208032 | 162.141 | C6H10O5 | 97.000 | OC(=O)CCOCCC(O)=O | 250mg | 279709653
eMolecules 2100306-71-4 | Bromo-PEG3-CH2CO2tBu | Broadpharm | MFCD30723231 | 327.215 | C12H23BrO5 | 98.000 | CC(C)(C)OC(=O)COCCOCCOCCBr | 500mg | 343283690
Bromo-PEG3-CH2CO2tBu | Broadpharm | 2100306-71-4 | MFCD30723231 | 327.215 | C12H23BrO5 | 98.000 | CC(C)(C)OC(=O)COCCOCCOCCBr | 500mg | 343283690
(=O)OCCNC(=O)OCCOC)OC(=O)CCCCCCCCCCCCC | 5mg | 718091915](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502486701.JPG-250.jpg)
eMolecules 474922-82-2 | 14:0 PEG PE, MW 550 | Broadpharm737.953 | C37H72NO11P | 95.000 | CCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(=O)OCCNC(=O)OCCOC)OC(=O)CCCCCCCCCCCCC | 5mg | 718091915
14:0 PEG PE, MW 550 | Broadpharm | 474922-82-2737.953 | C37H72NO11P | 95.000 | CCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(=O)OCCNC(=O)OCCOC)OC(=O)CCCCCCCCCCCCC | 5mg | 718091915