Protein Modification Reagents
Medchemexpress LLC Tos-peg4-nh-boc (PROTAC linker 7) | 1246999-33-6 | ≥98.0% | 1 G
Tos-PEG4-NH-Boc (PROTAC Linker 7) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. PROTACs consist of two different ligands connected by a linker; one ligand is for an E3 ubiquitin ligase, and the other is for the target protein. PROTACs utilize the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- Peg-based PROTAC linker
- Used in the synthesis of PROTACs
- Consists of two different ligands connected by a linker
- Utilizes the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
Medchemexpress LLC Bromoacetamido-PEG4-C2-Boc | 1807521-00-1 | 1 G
Bromoacetamido-PEG4-C2-Boc is a laboratory chemical used for the manufacture of substances. It is stable under recommended storage conditions.
- Harmful if swallowed
- Causes skin and serious eye irritation
- May cause respiratory irritation
- Store in a cool, well-ventilated area away from direct sunlight and ignition sources
- Recommended storage for pure form: -20°C for 3 years or 4°C for 2 years
- Recommended storage for in solvent: -80°C for 6 months or -20°C for 1 month
Medchemexpress LLC HS-PEG5-CH2CH2NH2 hydrochloride | 1446256-16-1 | 98.0% | 25 MG
HS-PEG5-CH2CH2NH2 hydrochloride is a PROTAC linker belonging to the PEG class, used for synthesizing PROTAC molecules. It is stable under recommended storage conditions and classified as not a hazardous substance or mixture.
- Used for synthesizing PROTAC molecules
- PROTAC linker belonging to the PEG class
- Stable under recommended storage conditions
- Not classified as a hazardous substance or mixture
Medchemexpress LLC Mal-PEG2-oxyamine | 1146245-73-9 | MFCD00209801 | 95.0% | 244.24 g·mol⁻¹ | C10H16N2O5 | 5 MG
Mal-PEG2-oxyamine is a PEG-based bifunctional linker used in the synthesis of proteolysis-targeting chimeras (PROTACs). It contains a maleimide group and an oxyamine moiety separated by a PEG2 spacer, enabling thiol-maleimide coupling and oxime ligation for efficient bioconjugation. The free base can be prone to instability; a TFA salt is available to improve stability.
- Bifunctional maleimide and oxyamine reactive groups.
- PEG2 spacer provides flexibility and improved solubility.
- Compatible with thiol conjugation and oxime ligation chemistries.
- Offered as a small-scale reagent (e.g., 5 mg) with reported purity around 95%.
Medchemexpress LLC Propargyl-PEG4-O-C1-NHS ester | 1161883-51-7 | 25 MG
Propargyl-PEG4-O-C1-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. It also functions as a click chemistry reagent, containing an Alkyne group that can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. PROTACs utilize the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Functions as a click chemistry reagent
- Contains an Alkyne group for CuAAc reactions
- Enables selective degradation of target proteins
![eMolecules Azido-PEG3-CH2CO2-NHS | Broadpharm | 1092654-47-1 | MFCD29067172 | 330.297 | C12H18N4O7 | 98.000 | [N-]=[N+]=NCCOCCOCCOCC(=O)ON1C(=O)CCC1=O | 500mg | 393649404](https://assets.fishersci.com/TFS-Assets/CCG/product-images/VN00128114-NC2000670.JPG-250.jpg)
eMolecules Azido-PEG3-CH2CO2-NHS | Broadpharm | 1092654-47-1 | MFCD29067172 | 330.297 | C12H18N4O7 | 98.000 | [N-]=[N+]=NCCOCCOCCOCC(=O)ON1C(=O)CCC1=O | 500mg | 393649404
Azido-PEG3-CH2CO2-NHS | Broadpharm | 1092654-47-1 | MFCD29067172 | 330.297 | C12H18N4O7 | 98.000 | [N-]=[N+]=NCCOCCOCCOCC(=O)ON1C(=O)CCC1=O | 500mg | 393649404
Medchemexpress LLC M-PEG4-hydrazide | 1449390-68-4 | C10H22N2O5 | 10MG
m-PEG4-hydrazide is a methoxy-terminated PEG4 linker containing a terminal hydrazide functional group. It is used as a spacer in PROTAC design and other bioconjugation workflows, enabling hydrazone formation with aldehydes while improving solubility and conformational flexibility. Supplied for research use; follow laboratory safety and handling guidance.
TARGETMOL CHEMICALS INC PEGAMOTECAN 5MG
Also available in 1 mg 10 mg 25 mg 50 mg and bulk. Please contact Fisher for quotes. Pegamotecan (PEG-camptothecin) is a topoisomerase I (TOP1) inhibitor with anticancer activity and it is used in the treatment of esophageal non-small cell lung and pancreatic cancers. purity: 97%
Medchemexpress LLC Mal-PEG2-NHS ester | 1433997-01-3 | MFCD24539465 | 98.6% | 354.31 | C15H18N2O8 | 100 MG
Mal-PEG2-NHS ester is a bifunctional PEG linker designed for bioconjugation, combining a maleimide moiety for thiol coupling with an NHS ester for amine coupling to enable antibody-drug conjugate (ADC) and other conjugation chemistries.
- Non-cleavable dual-reactive linker enabling site-specific conjugation.
- Two-unit PEG spacer increases hydrophilicity and solubility.
- Maleimide group reacts selectively with thiol groups.
- NHS ester reacts with primary amines for stable amide bond formation.
- Available in small-scale quantities suitable for research use.
- Stored and handled to preserve stability: long-term frozen storage recommended.
Cayman Chemical BIOnT PROTAC Fragmnt lbrar 5mg
Customers are supplied with the following data package for EAch fragment purchases: • Aqueous buffer 1H NMR raw data file • Structures and physiochemical properties in an sd file • SPR Clean Screen results The parameters used in the design of the library are: • Heavy atoms ≤ 16 • clogP ≤ 3 • Hydrogen bond donors ≤ 1 • Hydrogen bond acceptors ≤ 3 • tPSA ≤ 60 • Rotatable bonds ≤ 3
Medchemexpress LLC 4,7,10,13-tetraoxapentadecanoic acid, 15-hydroxy-, 1,1-dimethylethyl ester | 518044-32-1 | 99.3% | 322.39 g/mol | C15H30O7 | 10 G
Hydroxy-PEG4-(CH2)2-Boc is a PEG-based linker reagent used for conjugation chemistry, including antibody-drug conjugates (ADCs) and proteolysis-targeting chimeras (PROTACs). It provides a hydrophilic four-unit polyethylene glycol spacer with a terminal hydroxy group and a Boc-protected tert-butyl ester, intended for research use only.
- Provides a four-unit PEG spacer with terminal hydroxy functionality.
- Contains a Boc-protected tert-butyl ester compatible with common synthetic workflows.
- High reported purity suitable for conjugation and linker chemistry.
- Available in multiple pack sizes, including 10 G.
- Stable under recommended storage conditions for long-term use.
Medchemexpress LLC Methyltetrazine-PEG5-alkyne | 1802907-97-6 | MFCD28334550 | 98.0% | C20H26N4O5 | 10MG
Methyltetrazine-PEG5-alkyne is a PEG-based linker reagent containing a methyltetrazine moiety and a terminal alkyne, intended for bioorthogonal conjugation and PROTAC linker synthesis. Supplied as a high-purity research chemical, it is suitable for click chemistry and bioconjugation workflows and is soluble in DMSO.
- Contains methyltetrazine and terminal alkyne functional groups.
- PEG5 spacer provides flexibility and solubility.
- High purity (98.0%) for reliable experimental results.
- Soluble in DMSO for easy handling and reaction setup.
- Available in small quantities suitable for research workflows.
STA PHARMACEUTICAL US LLC Fmoc-NH-PEG20-CH2CH2COOH | 5 g | CAS 1952360-93-8 | MDL MFCD21363316
Fmoc-NH-PEG20-CH2CH2COOH is a Amino Acid reagent (Subcategory: PEG AA) sold by WuXi TIDES. Offered in 5 g. Store at 4 °C. SDS available for reference.
Specifications
- CAS: 1952360-93-8
- MDL: MFCD21363316
- InChIKey: YIKBHNBKAGGRHQ-UHFFFAOYSA-N
- Molecular Weight: 1192.397
- Molecular Formula: C58H97NO24
- Purity: ≥95%
- Container Type: 30 mL HDPE
- Pack Size: 5 g
- Net Weight: 5 g
- Gross Weight: 16.5 g
- Commodity Code: 29242970
- Country Of Origin: China
- IUPAC: 1-(9H-fluoren-9-yl)-3-oxo-2,7,10,13,16,19,22,25,28,31,34,37,40,43,46,49,52,55,58,61,64-henicosaoxa-4-azaheptahexacontan-67-oic acid
- SMILES: O=C(CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCNC(OCC1C2=C(C=CC=C2)C3=C1C=CC=C3)=O)O
Medchemexpress LLC Cholesterol-PEG 600 | 69068-97-9 | <1% | 1055.60 g/mol | C68H110O8 | 250 MG
Cholesterol-PEG 600 is a cholesterol-polyethylene glycol conjugate supplied for research use, provided as an off-white to light yellow oil. It is designed to introduce cholesterol moieties into membranes or to increase water solubility of lipid-modified constructs for biochemical and formulation studies.
- Cholesterol-PEG conjugate for membrane anchoring and formulation.
- Soluble in water (~60 mg/mL) with ultrasonic and warming.
- Appearance: off-white to light yellow oil.
- Storage: store pure material at -20°C; in solvent, -80°C for long term; aliquot to avoid freeze-thaw.
- Certificate of analysis shows total cholesterol ~20.4% and free cholesterol <1%.
- Available in multiple pack sizes from milligram to gram quantities.